Melatonin
A neurohormone that is produced in the brain by the pineal gland. When used as a dietary supplement, Melatonin has been shown to reduce sleep onset latency (the time it takes to fall asleep), increase REM sleep, and support a well-balanced sleep cycle.
Melatonin is formulated into these Clarocet products:
Clarocet PM

A Brief Introduction to Melatonin

Melatonin is a hormone produced in the pineal gland that regulates the sleeping and waking cycle as well as related functions within the body. Scientists classify the 2 types of Melatonin as endogenous, which means "occurring from within" and exogenous, or "occurring from outside of the body." The secretion of endogenous Melatonin is largely dependent on light/dark cycles, so it is inhibited during the day and stimulated at night. Exogenous Melatonin is primarily derived from synthetic origin and typically introduced into the blood stream by way of oral administration.

Clinical research shows that exogenous Melatonin may help to provide positive support for:

      • Occasional sleep difficulty caused by restlessness, nervous tension, occasional anxiety, mild to moderate mood changes, or jet lag
      • Daytime drowsiness and fatigue caused by occasional sleeplessness

Exogenous Melatonin maintains an excellent safety profile and it can be especially helpful for those experiencing sleep difficulties due to jet lag, shift work, and insufficient exposure to daytime sunlight. In low-dose studies (under 3 milligrams) exogenous Melatonin has been shown to have no adverse side effects and does not cause next-day grogginess.

How Melatonin is Thought to Work

The exact mechanism of action of exogenous Melatonin is not yet understood, although, there are multiple factors to explain its potential benefits:

      • Facilitates a shift in the natural production of melatonin
      • Modifies core body temperature, which in turn produces sleepiness
      • Exhibits a possible direct action on sleep-producing structures in the brain

It is known that endogenus Melatonin, which occurs naturally in the body, affects Circadian rhythm patterns. These work like an internal clock to regulate the schedules of bodily functions such as the sleep cycle. Multiple factors can affect how the body produces this neurohormone including underexposure to bright light and dramatic time zone shifts. When the body’s ability to produce Melatonin is compromised, exogenous Melatonin imitates the action of naturally occurring Melatonin in the regulation of sleep.

Melatonin Safety and Usage

Melatonin maintains an excellent safety profile when it is used as directed. For occasional sleep difficulty caused by restlessness, nervous tension, occasional anxiety, mild to moderate mood changes, or jet lag, a dose of 0.5mg-1mg is recommended nightly for two to six weeks.

What are the potential side effects of Melatonin?

Side effects have not been reported as a result of Melatonin use.

Does Melatonin adversely interact with prescription drugs?

Taking Melatonin in combination with prescription medications such as benzodiazepines, SSRIs, or SNRIs may cause drowsiness. If you are taking a prescription medication, it is recommended that you consult with your prescribing doctor before making any changes or additions to your current treatment plan.

Precautions and Safety For Users Taking Melatonin

      • Consult with your healthcare provider before beginning a wellness plan that includes dietary supplements like Melatonin
      • Do not take Melatonin if you are pregnant or nursing
      • Do not take Melatonin if you are currently taking a prescription MAOI
      • Do not operate vehicles or heavy machinery until you know how Melatonin affects you

Is Melatonin safe for children?

Clinical study data in children is limited and Melatonin should not be administered without the supervision of a professional healthcare provider.

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