A Brief Introduction to SAM-e

SAM-e (pronounced “sammy”) is a naturally occurring chemical that performs a wide range of functions throughout the body. In clinical study, SAM-e supplementation has demonstrated a broad spectrum of action to stimulate neurotransmitter productivity and maintain healthy cell-to-cell communication.

Italian researchers discovered the benefits of SAM-e in the 1970s, when they observed it to have substantial effects on individuals experiencing mood changes. SAM-e has been available over-the-counter in the United States since 1996 and is widely used as a dietary supplement to provide positive support for:

Depressed mood caused by everyday stress
Mild to moderate mood swings
Occasional nervousness, nervous tension, or anxiety

SAM-e is a vital component for the function of multiple body systems, aiding in the healthy balance of the neurotransmitters Serotonin and Dopamine, which are associated with mood balance and overall emotional well-being.

How SAM-e is Thought to Work

S-Adenosylmethionine (SAM-e) is a physiological agent that is formed in the liver when the essential amino acid methionine combines with adenosyl-triphosphate (ATP) by way of a process called methylation. It is then broken down and used in over 40 critical biochemical processes throughout the body. In laboratory settings, SAM-e has been shown to increase S-Adenosylmethionine levels in cerebrospinal fluid, which indicates that SAM-e is able to pass through the blood-brain barrier. SAM-e is a potential Natural Reuptake Inhibitor that may help to support a healthy neurotransmitter balance in the brain.

SAM-e Safety and Usage

SAM-e is an all natural dietary supplement that is available at most nutrition stores in the USA and Europe. It is available in varying doses from 50mg to 1000mg. Studies suggest that the optimum dosage range is between 200mg to 400mg daily.

What are the potential side effects of SAM-e?

The most commonly reported side effects of SAM-e are gastrointestinal. A very small percentage of users may experience heartburn, nausea and stomachache. No toxic effects have been reported in humans.

Does SAM-e adversely interact with prescription drugs?

SAM-e occurs naturally in the human body. Taking SAM-e while taking prescription medications is not known to cause adverse interaction. If you are taking a prescription medication, it is recommended that you consult with your prescribing doctor before making any changes or additions to your current treatment plan.

Precautions and Safety For Users Taking SAM-e

Parkinson’s disease patients should not take SAM-e with the drug Levodopa, as SAM-e may interfere with the drug’s actions.
Do not take SAM-e if you are pregnant or nursing.
Do Not Take SAM-e if you are currently taking a prescription MAOI.
SAM-e should be taken in moderation
Consult a physician if you plan on taking SAM-e with anti-depressants

Is SAM-e safe for children?

Clinical study data in children is limited and SAM-e should not be administered without the supervision of a professional healthcare provider.

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